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May 7, 2013PLoS ONEOpen Access

IL-21 Is Required for Optimal Antibody Production and T Cell Responses during Chronic Toxoplasma gondii Infection

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Authors

JSJason S. StumhoferUniversity of Arkansas for Medical SciencesJSJonathan S. SilverLahey Medical CenterCHChristopher A. HunterThe Wistar Institute

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Stumhofer et al. (2013) studied this question.

synapsesocial.com/papers/6aa455f4761b1b486c6ea9a2https://doi.org/10.1371/journal.pone.0062889
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IL-27 Limits IL-2 Production during Th1 Differentiation2006 · 218 citations
  2. 2Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii1992 · 573 citations
  3. 3Decreased Resistance of B Cell-Deficient Mice to Infection with <i>Toxoplasma gondii</i> Despite Unimpaired Expression of IFN-γ, TNF-α, and Inducible Nitric Oxide Synthase2000 · 239 citations
  4. 4IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses2010 · 829 citations
  5. 5Follicular Helper CD4 T Cells (T<sub>FH</sub>)2011 · 2,757 citations