Key result
Prox1 knockdown boosts CYP7A1 and PEPCK expression and bile acid synthesis in HepG2 cells.
Population
Human primary hepatocytes and HepG2 cells
Design
Preclinical
Authors
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Prox1 may modulate hepatic bile acid and glucose metabolism; leaves open its therapeutic targeting pending in vivo validation.
Prox1 acts as a novel co-regulator of HNF4alpha, playing a key role in regulating bile acid synthesis and gluconeogenesis in the liver.
Song et al. (2006) studied this question. Prox1 knockdown by small interfering RNA was evaluated on CYP7A1 and PEPCK mRNA expression and bile acid synthesis rate. Knockdown of endogenous Prox1 by small interfering RNA resulted in a significant increase of CYP7A1 and PEPCK mRNA expression and the rate of bile acid synthesis in HepG2 cells.
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