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September 1, 2026Journal of Biomedical Materials Research Part B Applied BiomaterialsOpen Access

Synthesis and Biological Evaluation of Cell Affinitive Oligo(poly(ethylene glycol) fumarate)‐Gelatin Methacrylate (OPF‐GELMA) Interpenetrating Network Hydrogels

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Authors

KZKatherine J ZhuXLXifeng LiuKGKaelyn L. Gasvoda

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Overview

Experimental study demonstrates enhanced mechanical strength and osteogenic differentiation in stem cell-seeded OPF-GelMA hydrogels, highlighting their utility for bone tissue engineering.

Key Points

  • To synthesize and evaluate an interpenetrating network hydrogel combining oligo(poly(ethylene glycol) fumarate) and gelatin methacrylate for mechanically robust and bioactive bone tissue regeneration.
  • Fabricated crosslinked interpenetrating network hydrogels by combining oligo(poly(ethylene glycol) fumarate) (OPF) with varying concentrations of gelatin methacrylate (GelMA).
  • Characterized hydrogel physical properties including swelling ratio, gel fraction, compressive stiffness, and internal microstructure.
  • Cultured rat bone marrow-derived mesenchymal stem cells (rBMSCs) on the scaffolds to evaluate cell proliferation and osteogenic differentiation via alkaline phosphatase activity and Runx2 expression.
  • Increasing GelMA content reduced hydrogel water swelling while significantly increasing gel fraction and compressive stiffness.
  • Elevated GelMA incorporation significantly promoted rBMSC proliferation and stimulated osteogenic differentiation, evidenced by increased alkaline phosphatase activity and upregulated Runx2 expression.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6aa45cec9ff49eff7618546ahttps://doi.org/10.1002/jbm.b.70155
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