Combinatorial chemistry is now widely used to synthesize large numbers of new chemical entities. New methods have been developed for early-stage pharma-cokinetic tests, to help decide which molecules have the properties required to make them efficacious and successful in the marketplace. Of the various physicochemical tests that are used to assess ADME, pKa (aqueous ionization constant) is the key to understanding how other properties will be affected by pH. A new method is described for rapid measurement of pKa of samples drawn from 96 well DMSO stock solutions.
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John Comer (2003) studied this question.
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