Chemoselective Trifluoromethylation of Methyl Esters Using an Et 3 GeNa/C 6 H 5 SCF 3 Combination: Efficient Synthesis of Trifluoromethyl Ketones

All articles of this category Various trifluoromethyl ketones were synthesized from the corresponding methyl esters by effective nucleophilic trifluoromethylation using an Et 3 GeNa/C 6 H 5 SCF 3 combination. This trifluoromethylation proceeded chemoselectively. When, cyclohexyl, i -propyl and t -butyl esters coexisted in the reaction system, only the methyl ester was easily transformed to the desired compounds in excellent yield. Furthermore, some protective groups were remained under this reaction condition. Et 3 GeNa - C 6 H 5 SCF 3 - trifluoromethylation - methyl ester - chemoselective