Key result
A 10-fold increase in hepatic triglyceride content was associated with a change in mean E/A ratio of -0.004 (95% CI -0.134 to 0.125) overall, and -0.109 (95% CI -0.186 to -0.032) in obese adults.
Why the study?
Is hepatic triglyceride content associated with left ventricular diastolic function in a population-based cohort?
Cross-Sectional
Is hepatic triglyceride content associated with left ventricular diastolic function in a population-based cohort?
Mean Difference: -0.004 (95% CI -0.134–0.125)
Fatty liver may pose a risk of myocardial dysfunction independent of metabolic syndrome components, particularly in obese individuals.
Supports hepatic fat-diastolic function link only in obese adults; hypothesis-generating and should not yet change practice.
PURPOSE: To investigate the association between hepatic triglyceride content and left ventricular (LV) diastolic function while taking potential confounding factors into account, including the components of the metabolic syndrome. MATERIALS AND METHODS: The study was approved by the institutional review board, and all participants gave informed consent. In this cross-sectional analysis of baseline data from the Netherlands Epidemiology of Obesity study, a population-based, prospective cohort study, participants (45% men; mean age ± standard deviation, 55.3 years ± 6.2) underwent magnetic resonance (MR) spectroscopy and MR imaging to assess hepatic triglyceride content and LV diastolic heart function (ratio of peak filling rates of the early filling phase and atrial contraction [E/A ratio]). Multivariate linear regression analysis was performed while adjusting for confounding factors, and results were additionally stratified according to body mass index. RESULTS: Adjustment for age, sex, heart rate, alcohol consumption, pack-years of smoking, all components of the metabolic syndrome, and visceral adiposity attenuated crude observed associations. A 10-fold increase in hepatic triglyceride content was associated with a change in mean E/A ratio of -0.004 (95% confidence interval [CI]: -0.134, 0.125) in the total study population, -0.194 (95% CI: -0.430, 0.042) in the normal-weight subgroup, 0.079 (95% CI: -0.090, 0.248) in the overweight subgroup, and -0.109 (95% CI: -0.186, -0.032) in the obese subgroup. CONCLUSION: Fatty liver itself could, at least in obesity, pose a risk of myocardial dysfunction above and beyond known cardiovascular risk factors that are clustered within the metabolic syndrome. The association in the obese subgroup was small, and future studies with larger samples sizes are required to investigate to what extent the association exists and differs in normal-weight, overweight, and obese persons to unravel its clinical relevance.
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Widya et al. (2016) conducted a cross-sectional in Obesity and Metabolic Syndrome. Hepatic triglyceride content vs. Lower hepatic triglyceride content was evaluated on Left ventricular (LV) diastolic heart function (ratio of peak filling rates of the early filling phase and atrial contraction [E/A ratio]) (Change in mean E/A ratio -0.004, 95% CI -0.134, 0.125). A 10-fold increase in hepatic triglyceride content was associated with a change in mean E/A ratio of -0.004 (95% CI -0.134 to 0.125) overall, and -0.109 (95% CI -0.186 to -0.032) in obese adults.
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