Key result
CHD risk factor interventions show consistent effects across diverse populations despite unclear optimal target levels.
Primary prevention through modifiable risk factor intervention remains the primary strategy for reducing future coronary heart disease risk globally.
Supports uniform interventions across populations; leaves optimal targets for definitive trials.
Coronary heart disease (CHD) is the leading cause of mortality in the industrialized world and that might also soon be the case in other parts of the world. There are several easily measured and potentially modifiable risk factors that account for a substantial proportion of the risk of CHD. The effect of risk factors interventions appears to be consistent in both genders, across different geographic regions, and by all ethnic groups, suggesting that approaches to prevention can be based on similar principles worldwide. Optimal target levels for serum cholesterol and blood pressure are not yet clear. Future risk CHD reduction will mainly be achieved by improved primary prevention.
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Stefan Agewall (2011) conducted a review in Coronary heart disease. Risk factor interventions for coronary heart disease prevention appear consistent across genders, geographic regions, and ethnic groups, though optimal target levels remain unclear.
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