1) Tissue ATP concentrations were determined in the cerebral hemispheres, liver and kidney in rats exposed to air at 1 atmosphere, and to 100% oxygen for 2 hours at 1 and 3 atmospheres, and 1 1/2 hours at 5 atmospheres. 2 Liver and kidney had normal ATP levels at 1 atmosphere and increased ATP levels at 3 atmospheres (39% and 18% respectively). 3 Cerebral hemispheres had markedly depressed ATP concentrations at 1 atmosphere (57%) and 3 atmospheres (34%). 4 Significant decreases in ATP levels occurred in cerebral hemisphere (54%), liver (44%), and kidney (63%) of rats exposed to 100% oxygen for 1 1/2 hours at 5 atmospheres. 5 The significance of the findings is discussed.
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Sanders et al. (1966) studied this question.