Platelet–macrophage cooperation drives IL-33–dependent type 2 lung immunopathology in a sex-biased manner

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BACKGROUND: Platelets amplify lung type 2 inflammation (T2I), but the underlying mechanisms remain incompletely understood. OBJECTIVE: ). METHODS: and IL-33 in naïve mice complemented the genetic models. Sex- and age-matched mice were randomly assigned, and histopathologic evaluations were performed under blinded conditions. RESULTS: Macs and expanded AT2 cells. CONCLUSION: sustains IL-33-driven expansion of AT2 cells and group 2 innate lymphoid cells, driving sex-biased amplification of T2I. This platelet-Mac axis may contribute to sex differences in type 2 inflammatory airway diseases such as asthma.