Antimutagenic Effect of Selenium and Vitamins Against the Genotoxicity Induced by Cobalt Chloride in Mice

The genotoxic effects of cobalt chloride (CoCl2) were studied in mice using different mutagenic end points in vivo. The possible protection provided by the antioxidant selenium and vitamins (ACE) against CoCl2 genotoxicity was also assessed. The results indicate that CoCl2 has genotoxic effects on mice somatic and germ cells. It induced a significant increase in the frequency of chromosomal aberrations in mouse bone-marrow and spermatocytes after single and repeated oral treatments. The induction of morphological sperm abnormalities was also confirmed in the present study. The supplemental selenium and vitamins (ACE) to reduce the genotoxic effect of CoCl2 was proved.