Key result
Jak-TGFβ cross-talk, triggered by ATGL-dependent adipocyte lipolysis and IL-6 family cytokines, links transient adipose tissue inflammation to beige adipogenesis.
The study identifies a Jak-TGFβ cross-talk pathway linking transient adipose tissue inflammation to beige adipogenesis, providing insights for therapeutic targeting of adipose tissue inflammatory pathways.
Suggests targets for adipose inflammatory pathways in metabolic disease; leaves open clinical translation of progenitor activation mechanisms.
expression before the core transcriptional adipogenic cascade was activated. This pathway cross-talk was triggered in stromal cells by ATGL-dependent adipocyte lipolysis and a transient wave of IL-6 family cytokines at the onset of adipose tissue remodeling induced by β3-adrenergic receptor stimulation. Our results provide insight into the activation of adipocyte progenitors and are relevant for the therapeutic targeting of adipose tissue inflammatory pathways.
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Babaeikelishomi et al. (2018) studied Adipose tissue inflammation and beige adipogenesis. β3-adrenergic receptor stimulation was evaluated on Activation of adipocyte progenitors and beige adipogenesis. Jak-TGFβ cross-talk, triggered by ATGL-dependent adipocyte lipolysis and IL-6 family cytokines, links transient adipose tissue inflammation to beige adipogenesis.
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