Evaluation of Hematological Parameters in Testicular Tumors

Objective: Recently, many hematological parameters have been frequently investigated as prognostic and predictive biomarkers for malignancies and inflammatory conditions, with the primary examples of these parameters being neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), platelet-lymphocyte ratio (PLR), and mean platelet volume (MPV).In this study, we aimed to investigate the relationship between hematological parameters and prognosis in patients with a diagnosis of testicular malignancy (TM) by evaluating them in comparison with patients that underwent varicocelectomy as a control group.Materials and Methods: A total of 187 patients that underwent radical inguinal orchiectomy due to the diagnosis of TM were included in Group 1 and 128 patients of similar age that underwent varicocelectomy using a similar incision in Group 2 as controls.Hematological and biochemical blood results were collected one day before radical orchiectomy.The parameters of NLR (neutrophil/lymphocyte counts), PLR (platelet/lymphocyte counts), and LMR (lymphocyte/ monocyte counts) were expressed as the ratios of indicated blood cell components.Following standard inguinal radical orchiectomy, T staging was performed based on the final histology samples, and clinical N and M staging using imaging modalities.Results: The mean ages of the patients were 26.5±7.1, and 25.1±8.1 years for Groups 1 and 2, respectively.The neutrophil counts, NLR, and PLR were significantly higher in Group 1, while the lymphocyte count, MPV, and LMR were significantly higher in Group 2 (p<0.001 for all).LMR was also significantly higher in patients with T1 stage TM, and NLR in those with >T1 stage TM (p<0.001).There was no significant difference between the patients with T1 and >T1 in terms of MPV and PLR.Conclusion: We determined NLR and LMR as parameters that can be used in the pathological staging of cases with TM.We consider that these hematological parameters have an important place in predicting the prognosis in this patient group.