Key result
Benfotiamine partially mitigates acute hyperglycemia-induced oxidative stress and cardiac dysfunction during ischemia-reperfusion.
Why the study?
Does benfotiamine treatment improve cardiac function during ischaemia-reperfusion in rat hearts exposed to acute hyperglycaemia?
Population
Isolated rat hearts and in vivo streptozotocin-treated rats
Comparison
Acute hyperglycaemia with or without… vs Normoglycaemia (11 mM glucose)
Design
Preclinical
Authors
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May link acute hyperglycaemia to MI via NOGPs; hypothesis-generating and requires clinical validation before practice change.
Does benfotiamine treatment improve cardiac function during ischaemia-reperfusion in rat hearts exposed to acute hyperglycaemia?
In a rat model, acute hyperglycaemia exacerbates ischaemia-reperfusion injury via non-oxidative glucose pathways, which can be partially mitigated by benfotiamine.
Mapanga et al. (2013) studied Acute hyperglycaemia and ischaemia-reperfusion injury. Acute hyperglycaemia (33 mM glucose) with or without benfotiamine (BFT) vs. Controls (11 mm glucose) was evaluated on Myocardial oxidative stress, NOGP activation, and cardiac contractile dysfunction. Acute hyperglycaemia generated myocardial oxidative stress and exacerbated cardiac contractile dysfunction during ischaemia-reperfusion, which was partially improved by benfotiamine treatment.
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