Key result
6 hepatitis A variants likely escaping vaccine protection emerge predominantly during an MSM outbreak.
Observational (n=128)
Highlights the emergence of hepatitis A vaccine escape variants, emphasizing the need for complete vaccination schedules, especially in immunocompromised individuals.
Alerts clinicians to potential hepatitis A vaccine escape in MSM outbreaks; leaves open whether antigenic variants necessitate updated vaccines.
Six hepatitis A virus antigenic variants that likely escaped the protective effect of available vaccines were isolated, mostly from men who have sex with men. The need to complete the proper vaccination schedules is critical, particularly in the immunocompromised population, to prevent the emergence of vaccine-escaping variants.
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Pérez‐Sautu et al. (2011) conducted an observational in Hepatitis A (n=128). Hepatitis A virus infection was evaluated on Presence of antigenic variants in the VP1 region. Six hepatitis A virus antigenic variants that likely escaped the protective effect of available vaccines were isolated, predominantly from an outbreak among men who have sex with men.
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