Key result
Diabetes linked to ~20% higher in-hospital mortality and complications in NVIE.
Why the study?
Data were lacking on clinical outcomes in patients with native valve infective endocarditis and diabetes mellitus.
Does diabetes mellitus worsen in-hospital outcomes in patients with native valve infective endocarditis?
Observational (n=76,385)
Yes
Does diabetes mellitus worsen in-hospital outcomes in patients with native valve infective endocarditis?
Diabetes mellitus is increasingly prevalent among patients with native valve infective endocarditis and is associated with significantly worse in-hospital clinical outcomes.
BACKGROUND: There is a lack of data on the clinical outcomes in patients with native valve infective endocarditis (NVIE) and diabetes mellitus (DM). AIM: To investigate (1) trends in the prevalence of DM among patients with NVIE; and (2) the impact of DM on NVIE outcomes. METHODS: without DM. Propensity match analysis and multivariate logistic regression were used to investigate study outcomes in in-hospital mortality, stroke, acute heart failure, cardiogenic shock, septic shock, and atrioventricular block. RESULTS: < 0.0001), were significantly higher in patients with DM. Independent predictors of mortality in NVIE patients with DM include hemodialysis, congestive heart failure, atrial fibrillation, staphylococcus aureus, and older age. CONCLUSION: There is an increasing prevalence of DM in NVIE and it is associated with poorer outcomes. Further studies are crucial to identify the clinical, and sociodemographic contributors to this trend and develop strategies to mitigate its attendant risk.
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Abe et al. (2021) conducted an observational in Native valve infective endocarditis (n=76,385). Diabetes mellitus vs. No diabetes mellitus was evaluated on In-hospital mortality (aOR 1.2, 95% CI 1.1-1.4, p=<0.0001). Diabetes mellitus was associated with a significantly higher risk of in-hospital mortality (11.9% vs 11.1%; aOR 1.2) and other complications in patients with native valve infective endocarditis.
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