Genetic Characterization of Highly Pathogenic Avian Influenza A(H5N6) Virus, Guangdong, China

activity.Thus, isolation of SHUV from malformed brains may indicate strong neurotropism of this putative pathogen.The possibility of its replication in the fetal nervous system should also be considered because an affected fetus that is born alive is likely a reservoir.Indeed, AKAV was identified in the hippocampus (only) of adult lactating cows (data not shown), and similar epidemiologic evidence might result from other Simbu virus infections.A serologic survey conducted in Israel during the 2001-2003 outbreaks of AHS showed reactivity of AINV to serum samples of ruminants in Israel's southern regions (3).Because AINV and SHUV are known to have a strong serologic cross-reaction, SHUV has likely previously infiltrated Israel.However, whether the seroreactivity results from AINV or SHUV remains unresolved.The emergence and reemergence of arboviruses should interest medical practitioners, particularly epidemiologists.The appearance of exotic viruses in unexpected locations might result in more severe pathology in newly invaded regions than in the original arbovirusendemic areas.Furthermore, SHUV has been detected in a child with febrile illness (2), a finding that suggests a potential zoonotic problem.