The pH-responsive PEGylated nanogels composed of the cross-linked poly[2-(N,N-diethylamino)ethyl methacrylate]-co-poly(2,2,2-trifluoroethyl methacrylate) gel core showed a remarkable on–off regulation of 19F magnetic resonance signal intensity (T2 values) as well as signal-to-noise ratios in response to extracellular pH 6.5 of tumor environment under 19F magnetic resonance spectroscopic imaging (MRS/I), demonstrating the utility of the PEGylated nanogels as solid tumor-specific 19F MRI/S nanoprobes.
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Oishi et al. (2008) studied this question.
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