Tunable Fabrication of 2D‐Layered Magnesium Nanosilicates With Hemostatic Properties

Tunable fabrication of inorganic two‐dimensional (2D) nanoclays is of substantial interest for fundamental studies and biomedical applications. Despite extensive work on inorganic biomaterials, layered silicate nanoclays remain a comparatively underexplored class of 2D systems. Here, we report an optimized hydrothermal method for the tunable fabrication of 2D layered magnesium nanosilicates (nSi). This approach yields disc‐like nanoclays with lateral dimensions of ~20–50 nm and thickness of ~1–2 nm. The nanosilicates exhibit rapid cellular internalization, controlled therapeutic release in vitro, and the ability to form shear‐thinning, thixotropic gels. Proteomic analyses indicate the formation of a protein corona enriched in factors associated with blood coagulation, consistent with in vitro clotting assays showing a concentration‐dependent reduction in clotting time, with decreases of ~50% at higher doses. In an in vivo rat liver‐laceration model, nanosilicate treatment reduced clotting time by ~75% and blood loss by ~45%, compared with controls. Collectively, these findings establish a tunable route for fabricating 2D‐layered magnesium nanosilicates and suggest their potential utility in hemostasis and wound‐management applications.