whom had received cephaloridine.We used a Levinthal agar-dilution technique with an inoculum of 0.004 ml. of a 1: 250 dilution of an overnight broth culture (104 organisms).The Table shows that for 27 of the 52 strains the M.I.C. was above the level likely to be obtained with the recommended dose.M.I.C. (pg.Iml.)40 20 10 5 4 3 2 1 Total No. of strains 6 21 13 1 3 6 1 1 52If this drug is used for the treatment of respiratory infections due to H. influenzae it is possible that it may not always be effective.-We are, etc.,
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Lane et al. (1965) studied this question.