Strategies for the Synthesis of Monohalogenated Analogues of Juglone: Unlocking the Potential of Regiospecific Synthesis Methodologies

This review article presents an overview of the different methodologies developed for the synthesis of monohalogenated analogues of juglone (1), which is a versatile structural scaffold with a wide range of biological activities.The synthesis of these monohalogenated analogues is of great importance in organic synthesis, especially for the pharmaceutical and agrochemical industries, as they are key intermediates in the regiospecificity of synthetic routes for the production of analogues and derivatives of 1.This review article presents the different regiospecific strategies used for the production of mono-chlorinated, monobrominated and mono-iodinated analogues of 1, in addition to highlighting their differences based on melting point and crystallographic studies.In short, this article provides a valuable reference for researchers in the area of organic synthesis who aim to develop innovative bioactive molecules.