Gold Nanoparticles Modified Electrode for the Determination of an Antihypertensive Drug

The nature of binding between Terazosin (TR) and gold nanoparticles (Au‐Nps) is investigated using UV‐vis and fluorescence spectroscopies, cyclic voltammetry, SEM, and EIS. The results suggest that Au‐Nps are effective carriers for TR. An electrochemical sensor for TR is introduced using Au‐Nps electrodeposited on carbon paste electrode. The effect of parameters including pH and scan rate on the response was investigated. A linear range from 8.0×10−9 to 5.4×10−5 mol L−1 with correlation coefficient of 0.9995 and detection limit of 1.2×10−10 mol L−1 was obtained. This sensor was used for determining TR spiked in urine, and excellent recovery results are achieved.