Key result
Digoxin increases vagal modulation of heart period by ~51% while enalapril shows no effect.
Why the study?
Does digoxin or enalapril alter RR interval variability in normal subjects?
RCT (n=20)
Double-blind
Randomized crossover
Does digoxin or enalapril alter RR interval variability in normal subjects?
In normal subjects, digoxin increases vagal modulation of heart period variability, whereas enalapril has no effect on these measures.
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Digoxin selectively boosts vagal heart period modulation in healthy subjects without mean RR change; reinforces distinct autonomic profile versus ACE inhibitors.
Kaufman et al. (1993) conducted an RCT in Normal subjects (n=20). Digoxin and enalapril vs. Placebo was evaluated on RR interval variability. Digoxin increased indexes of vagal modulation of heart period by up to 51% without changing mean RR interval, whereas enalapril did not change heart period variability.
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