Key result
Dronedarone is linked to fatal and near-fatal lung toxicity in two reported cases.
Why the study?
Is dronedarone use associated with fatal lung toxic effects?
Case Report (n=2)
Is dronedarone use associated with fatal lung toxic effects?
Dronedarone use may be associated with severe, potentially fatal lung toxicity, highlighting a critical safety concern.
May warrant vigilance for pulmonary toxicity with dronedarone; hypothesis-generating case data leave association unconfirmed.
Fatal Lung Toxic Effects Related to Dronedarone Use D ronedarone is a derivative of amiodarone that aimed to reduce the extracardiac adverse effects while preserving its antiarrhythmic effects for treatment of atrial fibrillation (AF). 1 In the ATHENA trial (A Placebo-Controlled, Double-Blind, Parallel Arm Trial to Assess the Efficacy of Dronedarone 400 mg bid for the Prevention of Cardiovascular Hospitalization or Death from Any Cause in Patients with Atrial Fibrillation/Atrial Flutter), 2 dronedarone reduced cardiovascular hospitalization and death in patients with nonpermanent atrial fibrillation (AF) with other cardiovascular risk factors.However, an experimental study 3 suggested that dronedarone might have toxic effects on the lung greater than or equal to amiodarone.We de-scribe 2 cases of fatal and near-fatal lung toxic effects associated with dronedarone use.
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Chung‐Wah Siu (2012) conducted a case report in Atrial fibrillation (n=2). Dronedarone was evaluated on Fatal and near-fatal lung toxic effects. Dronedarone use was associated with fatal and near-fatal lung toxic effects in two reported cases.
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