Microorganisms that enantioselectively hydrolyze 1 -cyanoalkyl acetates (aldehyde cyanohydrin) were screened.Candidatropicalis wasfound to be the best.The enzymesystem of this strain catalyzed the enantioselective hydrolysis of (S)-isomers, leaving behind the (i?)-acetates.The optical purities of recovered acetates were high as measured by ^-NMRanalysis in the presence of a chiral shift reagent.
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Ohta et al. (1988) studied this question.