Key result
Gestational diabetes linked to ~152 pg/mL lower neonatal BDNF levels versus healthy controls.
Why the study?
The influence of dietary and insulin-dependent gestational diabetes on BDNF blood levels in maternal-neonatal pairs compared to unaffected pregnancies had not been investigated.
Does gestational diabetes affect BDNF blood levels in maternal-neonatal pairs compared to healthy pregnancies?
Observational (n=293)
Does gestational diabetes affect BDNF blood levels in maternal-neonatal pairs compared to healthy pregnancies?
Mean Difference: -152.05
p-value: p=0.027
Gestational diabetes is associated with significantly lower BDNF levels in neonates compared to healthy pregnancies.
Lower neonatal BDNF in gestational diabetes should not change practice; hypothesis-generating for neurodevelopmental links in prospective studies.
The Objective of our study was to investigate the influence of dietary (dGDM) and insulin-dependent (iGDM) gestational diabetes (GDM) on BDNF blood levels of corresponding maternal-neonatal pairs and compare them to pregnancies unaffected by GDM. Blood samples from 293 maternal-neonatal pairs were analyzed. Statistical analysis was performed using multiple regression analysis for association of log-transformed maternal and neonatal BDNF levels in relation to GDM, gestational age, neonatal sex, and mode of delivery. This was followed by a 2:1 matching of healthy and diabetic pairs. Maternal and neonatal BDNF levels were lowest in the iGDM group, followed by the dGDM group and healthy controls (maternal: healthy 665 ± 562 (26–2343) pg/mL vs. dGDM 593 ± 446 (25–1522) pg/mL vs. iGDM 541 ± 446 (68–2184) pg/mL; neonate: healthy 541 ± 464 (9.5–2802) pg/mL vs. dGDM 375 ± 342 (1–1491) pg/mL vs. iGDM 330 ± 326 (47–1384) pg/mL). After multiple regression analysis and additional 2:1 matching neonatal log-BDNF was significantly lower (−152.05 pg/mL, p = 0.027) in neonates of mothers with GDM compared to healthy pairs; maternal log-BDNF was also lower (−79.6 pg/mL), but did not reach significance. Our study is the first to analyze BDNF in matched maternal-neonatal pairs of GDM patients compared to a metabolically unaffected control group.
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Jaskolski et al. (2022) conducted an observational in Gestational diabetes (n=293). Gestational diabetes (dietary and insulin-dependent) vs. Pregnancies unaffected by GDM (healthy controls) was evaluated on Neonatal and maternal BDNF blood levels (MD -152.05, p=0.027). Gestational diabetes was associated with significantly lower neonatal BDNF levels compared to healthy pairs (difference of -152.05 pg/mL, p=0.027).
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