Key result
Phosphodiesterases regulate cellular signaling by hydrolyzing cAMP and cGMP based on intracellular compartmentalization.
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This paper reviews the biological and pathological roles of phosphodiesterases as enzymes that hydrolyze cAMP and cGMP.
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Giorgi et al. (2024) studied this question. Phosphodiesterases regulate cellular signaling by hydrolyzing cAMP and cGMP second messengers temporally and spatially according to their intracellular expression and compartmentalization.
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