Four episodes of neutropenia or agranulocytosis possibly caused by the tetracyclic antidepressant drug, mianserin hydrochloride, were reported to the Australian Adverse Drug Reactions Advisory Committee during the first year of the drug's general availability in Australia. A small number of reports from other countries support the possibility of this association. Further surveillance to assess this potentially serious adverse effect is needed.
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A 1980 study studied this question.