All articles of this category A mild and convenient method for the preparation of amides from carboxylic acids and isocyanates is described. By using DMAP as a catalyst milder reaction conditions, are realised which also allow the conversion of α-chiral isocyanates, as well as α-chiral carboxylic acids without racemisation. DMAP - mixed anhydride - intramolecular transacylation - peptide synthesis - amides - isocyanates - condensation
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Schuemacher et al. (2001) studied this question.