Key result
Shear wave imaging of myocardial stiffness strongly correlates with isovolumic systolic pressure to noninvasively assess contractility.
Why the study?
To evaluate whether shear wave imaging could measure myocardial stiffness and whether myocardial stiffness accurately quantified myocardial function.
Preclinical study demonstrates real-time measurement of myocardial stiffness via shear wave imaging in isolated rat hearts, highlighting its role as a noninvasive contractility index.
OBJECTIVES: The goal of this study was to assess whether myocardial stiffness could be measured by shear wave imaging (SWI) and whether myocardial stiffness accurately quantified myocardial function. BACKGROUND: SWI is a novel ultrasound-based technique for quantitative, local, and noninvasive mapping of soft tissue elastic properties. METHODS: SWI was performed in Langendorff perfused isolated rat hearts (n = 6). Shear wave was generated and imaged in the left ventricular myocardium using a conventional ultrasonic probe connected to an ultrafast scanner (12,000 frames/s). The local myocardial stiffness was derived from shear wave velocity every 7.5 ms during 1 single cardiac cycle. RESULTS: The average myocardial stiffness was 8.6 ± 0.7 kPa in systole and 1.7 ± 0.8 kPa in diastole. Myocardial stiffness was compared with isovolumic systolic pressure at rest and during administration of isoproterenol (10(-9), 10(-8), and 10(-7) mol/l, 5 min each). Systolic myocardial stiffness increased strongly up to 23.4 ± 3.4 kPa. Myocardial stiffness correlated strongly with isovolumic systolic pressure (r(2) = [0.94; 0.98], p < 0.0001). CONCLUSIONS: Myocardial stiffness can be measured in real time over the cardiac cycle using SWI, which allows quantification of stiffness variation between systole and diastole. Systolic myocardial stiffness provides a noninvasive index of myocardial contractility.
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Pernot et al. (2011) studied Myocardial contractility assessment (n=6). Shear wave imaging (SWI) vs. Isovolumic systolic pressure at rest and during isoproterenol administration was evaluated on Correlation between myocardial stiffness and isovolumic systolic pressure (r2 = [0.94; 0.98], p=< 0.0001). Myocardial stiffness measured by shear wave imaging correlated strongly with isovolumic systolic pressure (r2 = [0.94; 0.98], p < 0.0001), providing a noninvasive index of myocardial contractility.
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