Key result
Pregnancy in severe AS is linked to aggravated HF symptoms but similar neonatal Apgar scores.
Observational (n=11)
No
Pregnancy in women with severe asymptomatic aortic stenosis carries a high risk of developing left-sided heart failure and arrhythmias, whereas outcomes are generally favorable for those with moderate or corrected stenosis.
May warrant closer HF surveillance in pregnant women with severe aortic stenosis; leaves open need for prospective confirmation on maternal-neonatal outcomes.
OBJECTIVE: The aim of this study was to provide data about the course and outcome of pregnancy in the women with aortic stenosis (AS) with special attention to complications in pregnant with severe AS, which was asymptomatic prior to conception.METHODS: Eleven pregnant women with different grades of AS were monitored in ambulatory and clinical conditions during pregnancy, childbirth and the post-partum period. The Apgar scores of the neonates born by mothers with AS were compared to those of neonates born by healthy mothers, using the variation statistical analysis.RESULTS: In the group with severe AS, asymptomatic prior to conception, aggravation of the NYHA functional class (FC) with left ventricular heart failure was observed. Pregnancy, childbirth and post-partum period were normal in the group with moderate aortic stenosis and in those with ventricular defects, corrected prior to conception. The sums of the Apgar scores for the whole group did not differ from those for the neonates, born by healthy mothers.CONCLUSION: The results suggest that there is a need of consensus for the complex of examinations, enabling diagnostic differentiation of pregnant women with severe AS requiring urgent defect correction and, the prognosis of pregnancy in women with asymptomatic severe AS.
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Гарнизов et al. (2014) conducted an observational in Aortic stenosis in pregnancy (n=11). Aortic stenosis vs. Healthy mothers was evaluated on Apgar score at 1 minute (p=>0.05). Pregnancy in women with severe aortic stenosis was associated with aggravation of heart failure symptoms, though overall neonatal Apgar scores did not significantly differ from those of healthy mothers.
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