Key result
Insulin-dependent diabetes linked to ~3-fold greater mortality risk after TAVI compared to non-diabetics.
Why the study?
Data on the impact of diabetes mellitus on clinical outcomes in patients undergoing TAVI were scarce and contradictory.
Does diabetes mellitus impact clinical outcomes in the short and medium term in patients with severe aortic stenosis undergoing TAVI?
Observational (n=132)
No
Does diabetes mellitus impact clinical outcomes in the short and medium term in patients with severe aortic stenosis undergoing TAVI?
Relative Risk: 0.81 (95% CI 0.58–2.01)
p-value: p=0.80
May warrant closer post-TAVI monitoring in insulin-dependent diabetes; leaves open whether risk is modifiable or causal.
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Dutra et al. (2019) conducted an observational in severe aortic stenosis (n=132). Diabetes mellitus vs. Non-diabetes mellitus was evaluated on Overall mortality at follow-up (RR 0.81, 95% CI 0.58-2.01, p=0.80). While diabetes mellitus overall did not influence mortality after transcatheter aortic valve implantation, insulin-dependent diabetes was associated with a 3.15-fold increased risk of total mortality compared to non-diabetics.
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