Key result
Vaccination-induced crying reduces the diastolic-to-systolic duration ratio versus quiet state in preterm infants.
Why the study?
Does crying induced by vaccination alter cardiac reserve parameters measured by phonocardiogram in preterm infants across different gestational ages?
Cross-Sectional (n=154)
No
Does crying induced by vaccination alter cardiac reserve parameters measured by phonocardiogram in preterm infants across different gestational ages?
Phonocardiogram-derived diastolic to systolic duration ratio (D/S) increases with gestational age and decreases during stress (crying) in preterm infants, suggesting its potential utility in assessing cardiac reserve.
Crying may signal reduced cardiac reserve in preterms; hypothesis-generating for phonocardiography, requires prospective validation before any practice change.
We aimed in this study to determine the cardiac reserve in preterm infants with phonocardiogram. One hundred and fifty-four preterm infants participated in this study. The ratio of the first heart sound to the second heart sound (S1/S2), the ratio of diastolic to systolic duration (D/S) and the cardiac contractility change trend after stimulation (CCCTS) were measured in all infants. The preterm neonatal S1/S2 decreased with increasing gestational age, but the differences between each gestational stage were not significant (p > 0.05), while the D/S significantly increased with increasing gestational age (p < 0.05). After crying induced by vaccination, the D/S was significantly lower than that in quiet state at each gestational stage (p < 0.05). The CCCTS increased with increasing gestational weeks, but the differences between each gestational stage were not significant (p > 0.05).
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Yang et al. (2011) conducted a cross-sectional in Preterm infants (n=154). Crying induced by vaccination vs. Quiet state was evaluated on Ratio of diastolic to systolic duration (D/S) (p=<0.05). Crying induced by vaccination significantly reduced the ratio of diastolic to systolic duration (D/S) compared to the quiet state across all gestational stages in preterm infants (p<0.05).
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