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Scleromyxedema is a chronic, idiopathic disorder associated with monoclonal gammopathy and characterized by dermal mucin deposition.1 A rare but severe complication of scleromyxedema is dermatoneuro syndrome (DNS), which presents with a flu-like prodrome, skin papules, fever, seizures, and coma. It can have catastrophic systemic effects with a substantial mortality rate of 21%2,3 requiring a multidisciplinary diagnostic approach for early detection and management.
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Liu et al. (2016) studied this question.
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