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A nanowire-based surface plasmon resonance (SPR) is investigated as a structure that offers improved sensor performance. The results calculated by rigorous coupled-wave analysis on a model using a hexanedithiol self-assembled monolayer (SAM) indicate that the resonant coupling between localized surface plasmons (LSPs) of nanowires affects the sensitivity enhancement substantially, while the LSP resonance in a single nanowire also contributes. SPR characteristics change significantly by applying a SAM, which can give rise to zero sensitivity for a given SAM. The results suggest that a properly designed nanowire-based SPR biosensor can enhance sensitivity by an order of magnitude with reasonable detection properties.
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Donghyun Kim (2006) studied this question.
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