Answers are grounded in this paper and cite their sources.
Skin test reactivity, lymphocyte transformation, and mononuclear cell tissue factor generation were evaluated both before and during systemic anticoagulation in 24 volunteers. Anticoagulation with warfarin decreased skin test induration and tissue factor generation, but lymphocyte trnasformation remained unchanged. An intact coagulation mechanism, including tissue factor generation, appears to be important for the development of skin test induration in humans.
No takes yet. Share an insight, caveat, or question.
Edwards et al. (1978) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: