Key result
Stroke before carotid endarterectomy is linked to ~15% higher long-term platelet counts versus TIA.
Why the study?
Do long-term platelet indices differ in patients with occlusive carotid artery disease based on their initial clinical presentation (stroke vs TIA)?
Observational (n=160)
No
Do long-term platelet indices differ in patients with occlusive carotid artery disease based on their initial clinical presentation (stroke vs TIA)?
Patients who underwent carotid endarterectomy for stroke have persistently higher platelet counts and mean platelet volumes long-term compared to those with TIA or controls.
Answers are grounded in this paper and cite their sources.
May warrant platelet monitoring in post-stroke CEA patients; leaves open whether indices predict recurrent events.
During the period 1965-1984 a total of 279 patients underwent carotid endarterectomy at the Tampere University Hospital; 160 of them were reexamined twenty-eight to two hundred nine months later to investigate whether there are any long-term differences in platelet properties according to the endpoint that led to operation. Platelet count, mean platelet volume (MPV), and plateletcrit were estimated and compared with the respective values for controls. Classified according to the indication for operation, patients with stroke had a significantly higher platelet count, 292 x 10(9)/L (SE 11), than patients with transient ischemic attack (TIA), 255 x 10(9)/L (SE 5, p < 0.01), or controls, 267 x 10(9)/L (SE 6, p < 0.05). Patients with stroke or TIA had a higher MPV than the controls. When the patients were grouped according to their physical condition at the time of the control examination, the largest platelets, 10.84 x 10(-15) L (SE 0.40), were found in the group of patients who felt well but who had a symptom or finding assumed to be due to a carotid disease.
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Valkila et al. (1994) conducted an observational in Occlusive Carotid Artery Disease (n=160). Stroke prior to carotid endarterectomy vs. Transient ischemic attack (TIA) or controls was evaluated on Platelet count (x 10^9/L) (p=< 0.01). Patients with stroke prior to carotid endarterectomy had a significantly higher long-term platelet count (292 x 10^9/L) compared to those with TIA (255 x 10^9/L, p<0.01) or controls.
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