Nanolobatolide (1), possessing a novel C(18) molecular structure, was isolated from the Formosan soft coral Sinularia nanolobata. The structure of 1 was established by extensive spectroscopic study and confirmed by X-ray diffraction analysis. A plausible biosynthetic pathway of 1 was proposed. Nanolobatolide (1) has been found to possess significant anti-neuroinflammatory and neuroprotective activities.
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Tseng et al. (2009) studied this question.
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