Key result
Combining participant-reported outcomes and sensor-derived backward walking velocity best predicts physical activity in multiple sclerosis.
Why the study?
Traditional clinical measures and participant-reported outcomes often fall short of fully capturing real-world mobility in multiple sclerosis, prompting evaluation of whether combining them with sensor-derived measures improves prediction of physical activity.
Does combining sensor-derived clinical measures and participant-reported outcomes better predict prospective physical activity levels in individuals with multiple sclerosis?
Observational (n=46)
Does combining sensor-derived clinical measures and participant-reported outcomes better predict prospective physical activity levels in individuals with multiple sclerosis?
Answers are grounded in this paper and cite their sources.
Integrating subjective participant-reported outcomes and objective sensor-derived measures improves the prediction of future physical activity in individuals with multiple sclerosis.
Multiple sclerosis (MS) is a chronic neurodegenerative disease characterized by mobility impairments that limit physical activity and reduce quality of life. While traditional clinical measures and participant-reported outcomes provide valuable insights, they often fall short of fully capturing the complexities of real-world mobility. This study evaluates the predictive value of combining sensor-derived clinical measures and participant-reported outcomes to better forecast prospective physical activity levels in individuals with MS. Forty-six participants with MS completed surveys assessing fatigue, concern about falling, and perceived walking ability (MSWS-12), alongside sensor-based assessments of gait and balance. Over three months, participants wore Fitbit devices to monitor physical activity, including step counts and total activity levels. Forward stepwise regression revealed that a combined model of participant-reported outcomes and sensor-derived measures explained the most variance in future physical activity, with MSWS-12 and backward walking velocity emerging as key predictors. These findings highlight the importance of integrating subjective and objective measures to provide a more comprehensive understanding of physical activity patterns in MS. This approach supports the development of personalized interventions aimed at improving mobility, increasing physical activity, and enhancing overall quality of life for individuals with MS.
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Monaghan et al. (2025) conducted an observational in Multiple sclerosis (n=46). Clinical, sensor-based, and self-reported measures was evaluated on Prospective physical activity levels (step counts and total activity levels). A combined model integrating participant-reported outcomes (MSWS-12) and sensor-derived measures (backward walking velocity) best predicted prospective physical activity in multiple sclerosis.
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