Key result
Anthracycline and trastuzumab cardiotoxicity is linked to abnormal T2 values in 29% of myocardial segments.
Why the study?
Does cardiac MRI with T2 mapping detect myocardial edema as a feature of acute cardiotoxicity in women with breast cancer receiving sequential anthracyclines and trastuzumab?
Observational (n=9)
No
Does cardiac MRI with T2 mapping detect myocardial edema as a feature of acute cardiotoxicity in women with breast cancer receiving sequential anthracyclines and trastuzumab?
Cardiac MRI with T2 mapping is being investigated to non-invasively detect myocardial edema associated with acute cardiotoxicity from sequential anthracycline and trastuzumab therapy in breast cancer patients.
Answers are grounded in this paper and cite their sources.
T2 mapping may detect edema in acute cardiotoxicity; leaves open prospective validation before clinical use.
Background Cardiotoxicity from cancer chemotherapy is an important cause of morbidity and mortality in breast cancer survivors. Left ventricular (LV) systolic dysfunction due to sequential use of anthracyclines and trastuzumab has been reported in up to 20-25% of patients. The pathophysiological changes associated with LV dysfunction have not been described non-invasively. We performed cardiac MRI (cardiac MR) with T2 mapping to assess whether myocardial edema is a feature of acute cardiotoxicity in women with breast cancer receiving sequential anthracyclines and trastuzumab.
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Thavendiranathan et al. (2014) conducted an observational in HER2+ breast cancer with subclinical cardiotoxicity (n=9). Cardiotoxicity during sequential anthracyclines and trastuzumab therapy vs. Pre-initiation of chemotherapy was evaluated on Proportion of myocardial segments with abnormal T2 values (> 59 ms) (p=<0.001). Breast cancer patients with cardiotoxicity during anthracycline and trastuzumab therapy had a significantly higher proportion of myocardial segments with abnormal T2 values compared to pre-therapy patients (29% vs 0%, p<0.001).
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