Key Points CD8+ Tregs possess a proapoptotic phenotype when compared with CD4+ Tregs, which is characterized by an inversion of the Bim/Mcl-1 ratio. Absence of Bim in adoptively transferred CD8+ Tregs results in augmented in vivo survival and superior protection from GVHD.
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Agle et al. (2018) studied this question.
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