Recent insights in vaccine delivery point out a distinct benefit for antigen to be delivered in a microparticulate form to professional antigen presenting cells. Encapsulation technology to produce antigen laden microparticles often requires complex handlings involving the use of organic solvents, chemical reactivity and/or high shear forces. These issues impair the practical and economical feasibility of such delivery systems. In this paper, we introduce a novel concept for the encapsulation of antigen within microparticles, making use of the lower critical solution temperature (LCST) behavior of a thermosensitive carrier polymer. Particle fabrication and characterization is demonstrated as well as their uptake by dendritic cells.
No takes yet. Share an insight, caveat, or question.
Geest et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: