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An established procedure for determining oxalate in human urine has been modified for rat urine. The daily excretion of oxalate by the male Wistar rat is 570-650 microgram. 2. Oxalate excretion in rat urine following i.p. administration of [14C]oxalic acid (1-70 mg/kg) has been studied. The rate and degree of excretion are dose-dependent. 3. The excretion of urinary oxalate by the rat has been quantified after administration of two oxalate-producing xenobiotics, alpha-chlorohydrin and 1,2-dibromo-3-chloropropane. 4. Oxalate inhibits the metabolism of glucose and lactate by isolated rat kidney tubules in vitro.
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Jones et al. (1981) studied this question.
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