The promoters of the p16INK4a and p15INK4b genes located at chromosome band 9p21 are frequently silenced by CpG island methylation in hematologic malignancies and solid tumors.[1][1] In chronic myelogenous leukemia (CML) the situation is confused because 2 reports have produced contradictory results
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Kusy et al. (2002) studied this question.
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