Hypermethylation of p15INK4B Gene in a Patient With Acute Myelogenous Leukemia Evolved From Paroxysmal Nocturnal Hemoglobinuria

To the Editor: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired disease resulting from somatic mutations in the PIG-A gene involving primitive hematopoietic stem cells. The PNH clones may have growth or survival advantages relative to normal clones that may promote their expansion,