Key result
Surgery and anesthesia induction are linked to slightly increased fibrinolytic activity with minimal blood loss impact.
Why the study?
Does surgery and anaesthesia alter the fibrinolytic activity of the blood in patients undergoing operations?
Observational (n=165)
Does surgery and anaesthesia alter the fibrinolytic activity of the blood in patients undergoing operations?
Fibrinolytic activity normally increases during surgery and anaesthesia, likely due to increased plasminogen activator, but probably has little influence on blood loss unless extreme.
Perioperative fibrinolytic increases warrant no routine intervention; extends physiological understanding but leaves open extreme-bleeding interactions.
Summary 165 patients undergoing various operations were studied for any variation in the fibrinolytic activity of the blood, as measured by a modified fibrin plate method. The fibrinolytic activity was found to increase somewhat already after induction of anaesthesia, and almost always slightly to moderately during the actual operation. This activity is believed to be due to an increase of the plasminogen activator in the blood, since it can be inhibited by administration of ε-aminocaproic acid. It is presumably a normal reaction and, unless extreme or combined with some coagulation disorder, it probably has but little influence on blood loss at operation.
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Andersson et al. (1962) conducted an observational in Undergoing surgery (n=165). Surgery and anaesthesia was evaluated on Variation in the fibrinolytic activity of the blood. Surgery and induction of anaesthesia were associated with a slight to moderate increase in blood fibrinolytic activity, which likely has little influence on blood loss.
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