In this article, a Lewis acid mediated 1,4‐addition/formal [3+2] cycloaddition reaction engaging functionalized β‐carboline and 1,4‐benzoquinone has been demonstrated. Application of this developed technology facilitated the construction of the challenging C‐9′–C‐15 quaternary center linkage in the dimeric indole alkaloid, haplophytine, and enabled the preparation of an advanced key intermediate en route to the total synthesis of this historical natural product.
No takes yet. Share an insight, caveat, or question.
Tian et al. (2011) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: