An assay for N-sulfate hexosamine has been adapted to the determination of the urinary excretion of N-sulfated glycos-aminoglycans. Values were obtained for N-sulfate glycosaminoglycan concentrations in the urine of 56 pediatric outpatients without clinical signs of mucopolysaccharidosis. Abnormal levels of N-sulfate glycosaminoglycan were found in 6 cases of mucopolysaccharidosis.
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Lagunoff et al. (1967) studied this question.
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