Key result
Sarcopenia affects ~10% of healthy adults aged 60 and older.
Why the study?
Although an inverse association between NT-proBNP and obesity exists, few major studies have evaluated the association between NT-proBNP levels and skeletal muscle mass in asymptomatic healthy adults.
Is decreased skeletal muscle mass associated with elevated NT-proBNP levels in asymptomatic healthy adults?
Meta-Analysis (n=58,404)
Is decreased skeletal muscle mass associated with elevated NT-proBNP levels in asymptomatic healthy adults?
In a relatively young and healthy adult population, severely low skeletal muscle mass is associated with a nearly 3-fold higher odds of elevated NT-proBNP levels.
Sarcopenia prevalence of 10% in adults ≥60 may prompt screening; leaves open whether low muscle mass elevates NT-proBNP in healthy populations.
BACKGRUOUND: Although an inverse association between the N-terminal prohormone brain natriuretic peptide (NT-proBNP) and obesity exists, only few major studies have assessed the association between NT-proBNP levels and skeletal muscle mass in asymptomatic healthy adults. Therefore, this cross-sectional study was conducted. METHODS: We assessed participants who underwent health examinations at Kangbuk Samsung Hospital in South Korea from January 2012 to December 2019. Appendicular skeletal muscle mass was measured using a bioelectrical impedance analyzer, and the skeletal muscle mass index (SMI) was calculated. Participants were divided into the control, mildly low skeletal muscle mass (LMM) (-2 standard deviation [SD] < SMI ≤-1 [SD]), and severely LMM groups (SD ≤-2) based on their SMI. The association between elevated NT-proBNP level (≥125 pg/mL) and skeletal muscle mass was assessed using multivariable logistic regression analysis with adjustment for confounding factors. RESULTS: This study enrolled 15,013 participants (mean age, 37.52±9.52; men, 54.24%; control, n=12,827; mildly LMM, n=1,998; severely LMM, n=188). Prevalence of elevated NT-proBNP was higher in mildly and severely LMM groups than in the control group (control, 1.19%; mildly LMM, 1.4%; severely LMM, 4.26%; P=0.001). The adjusted odds ratio (OR) of elevated NT-proBNP was significantly higher in severely LMM (OR, 2.87; 95% confidence interval [CI], 1.3 to 6.37) than in control (OR, 1.00; reference) or mildly LMM groups (OR, 1.24; 95% CI, 0.81 to 1.89). CONCLUSION: Our results showed that NT-proBNP elevation were more prevalent in participants with LMM. In addition, our study showed an association between skeletal muscle mass and NT-proBNP level in a relatively young and healthy adult population.
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Yoo et al. (2023) conducted a meta-analysis in Sarcopenia (n=58,404). General population (Aging) was evaluated on Overall prevalence of sarcopenia (95% CI 8-12). The overall estimated prevalence of sarcopenia in healthy adults aged 60 years and older was 10% in both men and women.
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