Physiological changes in the lipid metabolism of the domestic fowl produced by the administration of estrogens have been referred to frequently in the literature (Entenman, Lorenz and Chaikoff 1938; 1940; Lorenz, Chaikoff and Entenman 1938). Lorenz and his coworkers, however, were the first to suggest a practical application of these facts in fattening market poultry through the use of estrogen pellet implants (Lorenz, 1943; 1944). Articles by Jaap and Thayer (1945) further increased the interest among poultry men by calling attention to the possibility of fattening poultry by administering certain synthetic estrogens orally rather than by pellet implants as had been suggested by Lorenz. These articles also called attention to the fact that the physiological action of various synthetic estrogens was not necessarily similar for all poultry, since the order of estrogen activity was not parallel for chickens and turkeys.
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Heller et al. (1948) studied this question.