THE metabolism of the sex hormones by the liver is attracting increasing attention. Zondek (1934) and Heller (1940) have shown thatestradiol is inactivated on incubation with sliced or minced liver. Israel, Meranze and Johnston (1937) demonstrated that estrogens were inactivated after passage through a heart-lung-liver perfusion system but not after perfusion through a heart-lung system alone. Biskind (1941) and Biskind and Mark (1939) reported that pellets of estrone and estradiol benzoate were inactivated if implanted into the spleen. Talbot (1939) showed that in young female rats the uteri were stimulated by endogenous estrogen after the liver had been poisoned with carbon tetrachloride and alcohol. Golden and Sevringhaus (1938) demonstrated that endogenous estrogens were inactivated when the ovaries were implanted intraperitoneally. Cantarow and his coworkers (1943) have found that the estrogenic activity of liver bile obtained by duodenal intubation of women at full-term pregnancy was about 3 times that of the blood.
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John C. Allan (1944) studied this question.